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Buprenorphine

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Buprenorphine is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue, in the cheek, by injection, as a skin patch, or as an implant.

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Buy Buprenorphine Online Without Prescription

You can Buy Buprenorphine Online Without Prescription if you want to stay pain free. Buprenorphine is believed to be an effective drug to silence all types of body aches. Most of the healthcare specialists prescribe this medicine when it is required to blow off the pain at urgent bases.

Buprenorphine actually acts directly at the nervous system and suppresses the pain signals. Buprenorphine basically quiets the pain and does not diminish the reason behind the pain, hence it is recommended that you must take a medical advice after using it if you are buying it online.

What is Buprenex?

Buprenex is a brand-name prescription medication. It’s used to treat pain so severe that it requires a powerful type of pain reliever called an opioid. Before you take Buprenex, you must have already tried other pain treatments that didn’t help you. Buy Buprenorphine Online Without Prescription

Buprenex contains the drug buprenorphine, which is a type of opioid. Buprenex belongs to a group of drugs called partial opioid agonists. Compared to other opioids, Buprenex has a lower risk of addiction or misuse.

Buprenex is approved for use in adults and children ages 2 to 12 years.

Buprenex can be given in two different ways. A healthcare provider may give you the drug as an injection into your muscle (intramuscular). Or they may give you Buprenex as an injection into your vein (intravenous, which is also called IV).

Buprenex generic

Buprenex is a brand-name medication. Buprenex is also available in generic versions.

The generics are medications that contain buprenorphine, which is the same drug that’s in Buprenex. The generics are exact copies of Buprenex. But generics often cost less than the brand-name versions and are made by different companies.

Buprenex dosage

The Buprenex dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the pain you’re having
  • your clinical history, including previous pain medication
  • your age
  • other medical conditions you may have

Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Drug forms and strengths

Buprenex comes in a vial that contains the drug in a liquid form. Buprenex only comes in one strength: 0.3 mg/mL.

Buprenex can be given in two different ways. A healthcare provider may give you the drug as an injection into your muscle (intramuscular). Or they may give you Buprenex as an injection into your vein (intravenous, which is also called IV). Your doctor will decide which type of injection is right for you based on your condition and other medications you’re taking.

In people older than age 12 years, Buprenex is usually first given as a 1-mL injection. It contains 0.3 mg of Buprenex.

If your pain doesn’t go away, you may receive a second dose of Buprenex. The healthcare provider will wait 30 to 60 minutes after your first dose. The amount of the injection may vary based on your pain. But the second dose shouldn’t contain more than 1 mL (0.3 mg) of Buprenex.

Your doctor may want you to take more Buprenex if your pain doesn’t go away. Adults with severe pain may receive up to 2 mL (0.6 mg) for each dose.

Pediatric dosage

The recommended dosage for children ages 2 to 12 years is 2 to 6 micrograms per kilogram (mcg/kg) of body weight. This means that the dosage depends on how much your child weighs.

For example, the maximum dose for a 3-year-old child who weighs 31 pounds (14 kg) would be 84 mcg (14 kg x 6 mcg). This dose would be given as one injection.

If the child’s pain doesn’t go away after the first dose, the healthcare provider may give additional injections of Buprenex. There should be four to six hours between doses. But sometimes the healthcare provider may wait six to eight hours between doses. This depends on how the child responds to Buprenex.

What if I miss a dose?

If you miss an appointment to have an injection of Buprenex, call your doctor to reschedule.

To help make sure that you don’t miss a dose, write your treatment schedule in a calendar. You can also set reminders on your phone.

Will I need to use this drug long term?

No. Buprenex is a medication that you take only while you’re at a hospital or clinic.

A healthcare provider will give you Buprenex to reduce sudden episodes of pain. Once your pain and your medical condition improve, you’ll be sent home. If you have pain at home, your doctor may prescribe a different medication to help treat your pain.

Buprenex withdrawal

If you stop taking Buprenex suddenly, you may have withdrawal symptoms. These withdrawal symptoms include:

  • feeling restless
  • watery eyes
  • excess mucus in your nose
  • yawning more than often
  • excessive sweating
  • chills
  • pain in your muscles
  • pupils that are larger than usual
  • feeling irritable
  • anxiety
  • pain in your back or joints
  • weakness
  • abdominal (belly) cramps
  • insomnia (trouble sleeping)
  • nausea
  • anorexia
  • vomiting
  • diarrhea
  • increased blood pressure
  • increased breathing rate
  • increased heart rate

Call your doctor if you’re having symptoms of withdrawal that are severe or that don’t go away. They can recommend treatments to ease your symptoms.

Withdrawal symptoms in babies

If you take Buprenex for a long time when you’re pregnant, your baby may have neonatal opioid withdrawal syndrome.* This is a condition in which your baby is born with opioid withdrawal symptoms. If not treated, neonatal opioid withdrawal syndrome can be life-threatening. Buy Buprenorphine Online Without Prescription

Symptoms of neonatal opioid withdrawal syndrome include:

  • being fussy
  • crying much more than usual
  • muscles that twitch or seem tight
  • sweating
  • unusual sleeping patterns
  • high-pitched cry
  • tremors
  • vomiting
  • diarrhea
  • trouble feeding or not being able to gain weight
  • fever
  • seizures

If you took Buprenex while pregnant and your baby has any of these symptoms, call your doctor right away.

Buprenex uses

The Food and Drug Administration (FDA) approves prescription drugs such as Buprenex to treat certain conditions. Buprenex may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.

Buprenex for pain treatment

Buprenex is used to treat pain so severe that you need to take a powerful type of pain reliever called an opioid. Also, before you receive Buprenex, you must have already tried other pain treatments that didn’t help you.

Buprenex can be given in two different ways. A healthcare provider may give you the drug as an injection into your muscle (intramuscular). Or they may give you Buprenex as an injection into your vein (intravenous, which is also called IV). Your doctor will decide which type of injection is right for you based on your condition and other medications you’re taking. You’ll receive Buprenex in a hospital or a clinic.

In clinical studies, Buprenex was effective in helping ease severe pain. Researchers looked at how well Buprenex eased pain compared to morphine, an opioid drug. Buprenex and morphine were similarly effective in helping ease pain.

Buprenex for children

Buprenex can be used to treat severe pain in children ages 2 to 12 years.

In clinical studies, 960 children ages 9 months to 18 years received Buprenex. The effectiveness of Buprenex in these children was similar to that of adults who took it.

Buprenex overdose

Using more than the recommended dosage of Buprenex can lead to serious side effects.

Overdose symptoms

Symptoms of an overdose can include:

  • respiratory depression (slowed breathing)
  • pulmonary edema (excess liquid in your lungs)
  • blockage in your airways, which makes it hard to breathe
  • abnormal snoring
  • increasing sleepiness, which may make you unconscious or lead to coma
  • weakness in your muscles
  • cold or clammy skin
  • pupils that look larger or smaller than usual
  • bradycardia (slow heart rate)
  • low blood pressure

Buprenex and pregnancy

Clinical studies of pregnant women who took Buprenex suggest that the drug doesn’t cause birth defects. But using Buprenex during pregnancy can lead to problems during and after labor. Your baby may have trouble breathing while you’re giving birth.

In some cases, babies can develop neonatal opioid withdrawal syndrome.* This is a condition that can occur if you take Buprenex for a long time when you’re pregnant. Without treatment, neonatal opioid withdrawal syndrome can be life-threatening.

Animal studies suggest problems during pregnancy and harm to the baby if Buprenex is given to the mother. But studies in animals don’t always represent what happens in humans.

If you’re pregnant or plan to become pregnant, tell your doctor before you receive Buprenex. They can talk with you about the pros and cons of the medication.

Buprenex and birth control

Buprenex may lead to pregnancy complications. It may also harm your baby during and after birth. Talk to your doctor about your birth control needs while you’re using Buprenex.

Buprenex and breastfeeding

Studies looked at pregnant women who took high doses of buprenorphine that you take under your tongue. (Buprenorphine is the active ingredient in Buprenex.) The results showed that the buprenorphine was present in breast milk. But there isn’t enough information to say how this would affect a child.

In animal studies, pregnant animals who were given buprenorphine seemed to produce lower levels of breast milk. But animal studies don’t always reflect what happens in humans.

If you’ve been taking Buprenex, it’s recommended that you not breastfeed your child. Talk with your doctor about the best ways to feed your child.

Buprenex and alcohol

Taking Buprenex with alcohol* can be dangerous. It can lead to severe sedation (feeling drowsy and less alert), respiratory depression (slowed breathing), coma, or even death.

Alcohol is a type of substance called a central nervous system (CNS) depressant, which can relax your CNS. (Your CNS is made up of your brain and spinal cord.) If your CNS becomes too relaxed, your breathing may become too slow and lead to the problems mentioned above.

If you drink alcohol, talk with your doctor before taking Buprenex. They’ll try to limit how much you drink and monitor you during your Buprenex treatment.

Effects of Buprenorphine

Buprenorphine has proved to be an important drug among all the analgesics because of its quick pain relieving feature. Benefits of Buprenorphine are:

-Relieves acute pain
-Relieves chronic pain
-It is also used in combination with Naloxone to get rid of opioid dependency.

Buprenex side effects

Buprenex can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Buprenex. These lists don’t include all possible side effects.

For more information on the possible side effects of Buprenex, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.

More common side effects

The more common side effects of Buprenex can include:

  • sedation (feeling drowsy and less alert)
  • nausea
  • dizziness
  • headache
  • vertigo (feeling a loss of balance)

Most of these side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects

Serious side effects from Buprenex aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include the following:

  • Serotonin syndrome (high levels of a chemical called serotonin). (For symptoms, see “Side effect details” below.)
  • Life-threatening respiratory depression.* (For symptoms, see “Side effect details” below.)
  • Severe constipation. Symptoms can include:
    • fewer than three bowel movements each week
    • hard and dry feces
    • feeling full even after a bowel movement
    • blockage in your large intestine
  • Adrenal gland problems, including low levels of cortisol. Symptoms include:
    • tiredness and fatigue (lack of energy)
    • weak muscles
    • skin that gets darker in color
    • weight loss or lack of appetite
  • Allergic reactions. (For symptoms, see “Side effect details” below.)
  • Shock (your blood doesn’t reach your organs). Symptoms include:
    • fast or weak pulse, or the lack of a pulse
    • lightheadedness
    • shallow, fast breathing
    • clammy skin
    • loss of consciousness

Side effect details

You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Here’s some detail on some of the side effects this drug may or may not cause.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Buprenex. In clinical studies, allergic reactions to Buprenex were rare, but they did occur. Most of these allergic reactions were mild.

Symptoms of a mild allergic reaction can include:

  • rash
  • hives (itchy welts on your skin)
  • itching

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • bronchospasm (wheezing or trouble breathing that gets worse)
  • swelling of the face, lips, or airways
  • anaphylactic shock (sudden drop in blood pressure and trouble breathing)

Severe allergic reactions to Buprenex can be life-threatening. Call your doctor right away if you think you are having a severe allergic reaction to Buprenex. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency.

Constipation

If you take Buprenex, you may have constipation. Buprenex can affect the muscles in your colon, preventing waste from moving through your body. This can lead to constipation. If the constipation is severe or doesn’t go away, it can lead to other problems. These problems may include blocked intestines or a serious condition called paralytic ileus.

In clinical studies, constipation occurred in less than 1% of people who took Buprenex. Other forms of buprenorphine (the active ingredient in Buprenex) caused constipation in up to 13% of people who took the drug.

If you have constipation for more than three days after taking Buprenex, tell your doctor. They can suggest treatments to help you find relief.

Weight loss

Weight loss may or may not be a side effect of Buprenex. In clinical studies, weight loss didn’t occur in any people who took Buprenex. But weight loss has been reported with other forms of buprenorphine (the active ingredient in Buprenex).

If you’re concerned about losing weight while taking Buprenex, talk with your doctor. They can give you nutrition advice to help make sure you’re at a healthy weight.

Serotonin syndrome

If you take Buprenex, you may develop serotonin syndrome. Serotonin is a chemical that helps your brain work. Buprenex can increase the level of serotonin in your brain.

Serotonin syndrome is rare. But your risk of serotonin syndrome increases if you take Buprenex with other drugs that can increase levels of serotonin. (See “Buprenex interactions” section above to learn more.)

Symptoms of serotonin syndrome may include:

  • feeling confused
  • feeling irritable
  • anxiety
  • muscle spasms (twitches) or stiffness
  • body tremors or shaking
  • fast or abnormal heartbeat
  • nausea that doesn’t go away
  • diarrhea that doesn’t go away
  • hallucinations (seeing or hearing things that aren’t real)
  • increased size of your pupils
  • seizures

If untreated, serotonin syndrome can lead to coma and death.

If you have symptoms of serotonin syndrome, tell your doctor. Call 911 if your symptoms feel life-threatening or if you think you are having an emergency.

Life-threatening respiratory depression

Taking Buprenex can cause a condition called respiratory depression* in which your breathing becomes slow and weak. The condition can be severe, life-threatening, or even fatal. Your doctor will monitor you during your Buprenex treatment, especially when you first take the drug or if they increase your dose.

It’s not known how many people have developed respiratory depression after taking Buprenex. But respiratory depression is a known side effect of opioid drugs. According to one studyTrusted Source, buprenorphine is less likely to cause respiratory depression than fentanyl, another opioid that’s used to treat severe pain. (Buprenorphine is the active ingredient in Buprenex.)

Respiratory depression is more common in people who have breathing problems such as chronic obstructive pulmonary disease (COPD), are elderly, or are very ill.

Symptoms of respiratory depression can include:

  • feeling tired or sleepy during the day
  • shortness of breath
  • shallow or slow breathing
  • feeling confused or depressed
  • headaches that don’t go away
  • seizures
  • pale or blue skin, especially in your fingers, toes, or lips

Because of these symptoms, it could be dangerous to drive or operate machinery while taking Buprenex. Until you’re certain that Buprenex isn’t causing these symptoms, avoid such activities.

If you have symptoms of respiratory depression, tell your doctor. Call 911 if your symptoms feel life-threatening or you think you are having an emergency.

Side effects in children

Buprenex is approved for use in adults and children ages 2 to 12 years. The side effects in children are similar to those in adults.

Alternatives to Buprenex

Other drugs are available that can treat pain. Some may be better suited for you than others.

Examples of other drugs that may be used to treat severe pain include:

  • morphine (Arymo ER, Kadian, MorphaBond ER, MS Contin)
  • hydrocodone (Hysingla ER, Zohydro ER)
  • hydromorphone (Dilaudid, Exalgo)
  • oxycodone (Oxaydo, OxyContin, OxyFast, Roxicodone, Xtampza ER)
  • fentanyl (Duragesic)
  • meperidine (Demerol)
  • methadone (Dolophine, Methadose, Methadose Sugar-Free, Methadone Diskets)
  • tramadol (ConZip, Ultram, Ultram ER)
  • levorphanol (Levo-Dromoran)
  • oxymorphone (Opana, Opana ER, Numorphan HCl)
  • pentazocine (Talwin)
  • tapentadol (Nucynta, Nucynta ER)
  • butorphanol (Stadol)
  • nalbuphine (Nubain)

If you’re interested in finding an alternative to Buprenex, talk with your doctor. They can tell you about other medications that may work well for you.

How Buprenex is given

You’ll receive Buprenex in a hospital or a clinic. The drug can be given in two different ways. A healthcare provider may give you Buprenex as an injection into your muscle (intramuscular). Or they may give you the drug as an injection into your vein (intravenous, which is also called IV). Your doctor will decide which type of injection is right for you based on your condition and other medications you’re taking.

For an IV injection, the healthcare provider will place a needle in your vein and slowly inject Buprenex. An IV injection of Buprenex can take two minutes or longer.

Once your pain and your medical condition improve, you’ll be sent home. If you have pain at home, your doctor may prescribe a different medication to help treat your pain.

How often the drug is given

If your pain doesn’t go away after your first dose of Buprenex, you may be given a second injection. The healthcare provider will wait 30 to 60 minutes after your first dose. Your doctor may want you to take more Buprenex if your pain doesn’t go away.

How Buprenex works

The feeling of pain is the result of information moving across your body. When your body is hurt, your brain tells those parts of your body that they’re injured. As a result, you start feeling pain in those body parts.

Proteins called opioid receptors help regulate how these pain messages move between your body parts and your brain. Buprenex binds to opioid receptors in your brain and spinal cord. This action changes how your body senses pain and helps relieve your symptoms.

How long does it take to work?

When you’ll start feeling pain relief depends on how you receive Buprenex. If you receive the drug as an injection into your muscle (intramuscular), it may take up to 15 minutes to feel less pain. The pain relief may last for about six hours.

If you receive Buprenex as an injection into your vein (intravenous, which is also called IV), your pain may ease even sooner. You may have pain relief in less than 15 minutes. The effect will also last for about six hours.

Is Buprenex ever given by mouth?

No, Buprenex isn’t ever given by mouth. A healthcare provider may give you Buprenex as an intramuscular injection. Or they may give you the drug as an IV injection. Your doctor will decide which type of injection is right for you based on your condition and other medications you’re taking.

However, there are other medications very similar to Buprenex that are given by mouth. These include buprenorphine tablets that you take under your tongue (sublingual).

If you’re not comfortable getting injections, let your doctor know. They may be able to recommend a different form of pain relief.

Can I take Buprenex if I’m being treated for anxiety?

Maybe. Certain anxiety medications can interact with Buprenex and cause serious side effects. These include severe sedation (feeling drowsy and less alert), respiratory depression (slowed breathing), coma, and even death.

Anxiety medications can include benzodiazepines and other central nervous system (CNS) depressants.

Can I use Buprenex to treat opioid dependence?

No, you can’t. Using Buprenex alone to treat opioid dependence may cause you to become addicted* to Buprenex. (With opioid dependence, you need an opioid drug to function.)

However, you might be able to use a drug called naloxone to treat opioid dependence. Naloxone is often used with buprenorphine, which is the active drug in Buprenex. Examples of combinations of naloxone and buprenorphine that are available include:

  • Zubsolv, which is a drug that you take under your tongue (sublingual)
  • Bunavail, which is a drug that you take inside your cheek (buccal)

If you’re dependent on taking opioids, talk with your doctor. They can help you decide on the best treatment for you.

Where will I be given Buprenex treatments?

You’ll receive Buprenex at a hospital or a healthcare clinic. A healthcare provider may give you Buprenex as an injection into your muscle (intramuscular). Or they may give you the drug as an injection into your vein (intravenous, which is also called IV). Your doctor will decide which type of injection is right for you based on your condition and other medications you’re taking.

Because Buprenex has to be given by a healthcare provider, you can’t give yourself injections of the drug.

If you’re concerned about after you leave the hospital or clinic, talk with your doctor. They can recommend treatments for pain relief.

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